Aplastic Crisis as Primary Manifestation of Systemic Lupus Erythematosus
نویسندگان
چکیده
منابع مشابه
Aplastic crisis as primary manifestation of systemic lupus erythematosus.
Aplastic crisis is an unusual feature of systemic lupus erythematosus (SLE). We report the case of a 54-year-old woman presenting with both (extravascular) Coombs-positive hemolytic anemia and laboratory findings of bone marrow hyporegeneration with concomitant severe neutropenia. A bone marrow biopsy confirmed aplastic crisis. Diagnostic work-up revealed soaring titers of autoantibodies (anti-...
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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. The most common hematologic finding is anemia, leukopenia, thrombocytopenia and secondary antiphospholipid syndrome with recurrent abortion and thrombosis. The autoimmune fibrosis of bone marrow is another manifestation of autoimmune disease especially SLE, that must be correctly differentiated from primary myelofibrosis.
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The present report documents the occurrence of lupus nephropathy as the sole initial manifestation of systemic lupus erythematosus (SLE). Despite the absence of initial systemic signs characteristic of SLE, the diagnosis was confirmed on the basis of the renal histopathologic features and serological studies. Subsequent follow-up demonstrated systemic features of the disease in each of the four...
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Both stroke and transient cerebral ischaemic attacks occurring in younger patients may be due to systemic lupus erythematosus. Other clinical features of the disease may be absent. Initially the ESR may be normal, as may serological tests. Seizures may occur at or near the time of the vascular events. Systemic lupus erythematosus may be the cause of an asymptomatic cerebral infarct or multi-inf...
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ژورنال
عنوان ژورنال: Onkologie
سال: 2011
ISSN: 1423-0240,0378-584X
DOI: 10.1159/000331069